10 CentraleSupélec startups in the Challenges ranking

Le Challenges magazine unveiled his ranking of the 100 startups to follow for investment in 2025. Ten of them were created by CentraleSupélec graduates and / or accompanied by 21st by CentraleSupélec.

37 degrés : co-founded by Matthieu Gilquin, a CentraleSupélec alumnus, and Gaëlle Burcklé, the startup offers a solution so that men can better manage contraception in the face of the dissatisfaction of many women with the pill, through boxers that prevent sperm production. After receiving a French Tech grant of 30 euros from Bpifrance in February 000, the startup wants to raise funds to carry out pre-clinical and clinical trials for the commercialization of its product in 2025.

ReACT Therapeutics : Co-founded by Lise Clément-Demange, Émile Roussel, and Renaud Vaillant, alumni of CentraleSupélec, this startup has found a way to block the protein responsible for drug resistance in cancer treatments. Indeed, the BCRP protein is responsible for the rejection of approximately 40 anticancer treatments used in 14 types of cancer. At this stage, the young company is focusing its efforts on colon and pancreatic cancers, among the most common. For the molecule it has developed, patented and in preclinical testing, it is aiming for a combination with the treatment Irinotecan, a key chemotherapy in these cancers.

LumiSync: Co-founded by Rémy Braive, alumnus of the Université Paris-Saclay and professor-researcher at the Centre for Nanoscience and Nanotechnology (C2N - Univ. Paris-Saclay / CNRS / Univ. Paris Cité), Giuseppe Modica, researcher at C2N, and Alexis Jonville, this company aims to circulate data more quickly, while achieving significant energy savings. Lumisync, specializing in telecoms, data centers, and aerospace, presents itself as the only company to develop a 100% photonic oscillator. Although slightly more expensive than current high-performance models, it is manufactured at the Centre for Nanoscience and Nanotechnology, where the company, supported by the 21st accelerator at CentraleSupélec, has clean rooms for prototyping. Faced with the explosion in AI uses, its all-optical systems could reduce data center costs by 50%, while dividing their energy consumption by 70 and their latency by 100. Ultimately, Lumisync aims to develop complementary photonic components to establish itself in the design and production of photonic integrated circuits.

Epyr : co-founded by Léa Dardenne and Bastien Oggeri, alumni of CentraleSupélec, the startup is tackling industrial heat. Their technology makes it possible to store energy produced by intermittent renewable energies (wind, solar) during periods of surplus, in the form of heat, to release it when an industrialist needs it. This solution is designed for all processes requiring steam or hot water at medium and high temperatures (above 100 °C), such as sterilization in the food industry or drying in the paper industry.

Swaive : founded by Karen-Laure Mrejen, a CentraleSupélec alumna, is an investment platform that only offers risk-free products for savers who have already filled their Livret A and LDDS savings accounts.

Osiris : co-founded by Henri Desesquelles, alumnus of CentraleSupélec, Rodolphe Cockenpot and Léon Guyart, has developed a robot capable of reducing the volume of water for farms by 30% by bringing water as close as possible to the plant. This robot is completely energy autonomous because it is equipped with a turbine that transforms the water pressure into energy and it moves by self-guidance, thanks to an onboard GPS, at the very cautious speed of 1 km/h. It also has a buffer battery that allows it to add up to an hour of autonomy in the event of a problem.

Heptalytics : faced with the explosion of payment fraud, Heptalytics, co-founded by Alexandre David, who graduated from CentraleSupélec, and Brice Le Grignou, this startup provides an AI assistant capable of detecting and anticipating fraudulent acts by criminals.

Neuralk-AI : co-founded by Antoine Moissenot and Alexandre Pasquiou, alumnus of CentraleSupélec and doctor of the University of Paris-Saclay, the startup offers a conversational AI specifically trained to provide reliable predictions from data in the form of tables, widely used in the commercial sector but poorly exploited by existing AI.

NRJx : co-founded by Alexandre Kipp and Cédric Faucheux, alumni of CentraleSupélec, this startup has developed a SaaS platform capable of collecting and analyzing data from industrial machines in real time, in order to optimize the energy consumption of factories. Already adopted by around thirty companies, particularly in plastics, packaging and agri-food, this solution responds to a strategic challenge for these sectors, where margins are low and energy optimization is becoming a key lever for competitiveness.

Firecell : co-founded by Olivier Dhotel, Claude Seyrat, Ulla Saari and Sandrine Legrand, a CentralSupélec alumna, aims to meet the connectivity needs of businesses by offering them a secure 5G network. Its turnkey open source software allows the deployment of a highly secure mobile network over an area of ​​30 m000, in order to connect field teams to business applications, mobile equipment and robots, surveillance cameras and geolocate tools.