Research Published on 10/29/2020

A recent study has shown that artificial intelligence can extract clinical and biological information from CT images to establish the severity of the disease and the prognosis of patients with Covid-19. Physicians and researchers from Institut Gustave Roussy, Assistance Publique-Hôpitaux de Paris, CentraleSupélec, Université de Paris, Université Paris-Saclay, Inserm, Inria and TheraPanacea have established a digital signature of biomarkers predictive of the evolution of Covid-19. By identifying patients at risk of developing severe forms and requiring ventilation assistance, this AI could help hospitals to prioritize patient management according to their vital urgency. These results were published in the journal Medical Image Analysis

Chest CT is widely used for the management of coronavirus pneumonia. In addition to helping to diagnose the disease, it plays a prognostic role by visually assessing the extent of lung damage. In this retrospective study, physicians and researchers developed an end-to-end artificial intelligence solution that allows an experienced radiologist to quantify Covid-19 as accurately as an experienced radiologist, to assess the severity of the disease and its short-term prognosis.

The AI was trained and validated on the CT images of 478 patients from five independent cohorts who had previously been diagnosed with Covid-19 by RT-PCR test. The group of patients studied had 110 severe cases of which 6% died from Covid-19 and 17% were intubated.

Using a deep learning approach and exploiting 2D and 3D convolutional neural networks, the researchers taught the AI to automatically recognize the areas where the disease was characteristic (frosted glass structure) on the scanner images. To do so, they used a dataset of more than 20,000 scanner slices annotated by 15 independent and experienced radiologists. The algorithm then determined 10 clinically interpretable biomarkers based on the extent and heterogeneity of the disease, lung involvement and cardiac preservation.

By correlating these biomarkers with patient age and gender and clinical data, the AI learned through a set of supervised classification methods to assess disease severity and short-term prognosis of patients, and thus identify those who will develop severe symptoms associated with respiratory and resuscitation needs. It would also be of interest to propose early, and to avoid the need for resuscitation, drugs currently being evaluated in severe forms of Covid-19.

"The work is ongoing and a permanent enrichment of the dataset is planned. 11,000 scanners that will very soon be integrated have already been annotated as part of the STOIC project promoted by AP-HP and coordinated by Pr Marie-Pierre Revel of the AP-HP Cochin Hospital. Thanks to the AI.Dream project financed by Bpifrance, a clinical deployment is planned in 2021 in partnership with GE Healthcare," concludes Pr Nikos Paragios at Centrale Supélec/University Paris-Saclay, President of TheraPanacea, and member of the PRISM National Center for Precision Medicine.

AI-Driven CT-based quantification, staging and short-term outcome prediction of COVID-19 pneumonia
Medical Image Analysis, advanced online publication on October 15, 2020


Guillaume Chassagnona,b,c, Maria Vakalopouloud,e,f, Enzo Battistellad,e,f,g, Stergios Christodoulidish,i, Trieu-Nghi Hoang-Thia,Severine Dangearda, Eric Deutschf,g, Fabrice Andreh,i, Enora Guilloa, Nara Halma, Stefany El Hajja, Florian Bomparda, SophieNeveua, Chahinez Hania, Ines Saaba, Ali ́enor Campredona, Hasmik Koulakiana, Souhail Bennania, Gael Frechea, Maxime Barata,b, Aurelien Lombardj, Laure Fournierb,k, Hippolyte Monnierk, Teodor Grandk, Jules Gregoryb,l, Yann Nguyenb,m, Antoine Khalilb,n, Elyas Mahdjoubb,n, Pierre-Yves Brilleto,p, Stephane Tran Bao,p, Valerie Boussonb,q, Ahmed Mekkir,s,t, Robert-Yves Carlierr,s,t, Marie-Pierre Revela,b,c, Nikos Paragiosd,f,j

a Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France
b Université de Paris, 85 boulevard Saint-Germain, Paris 75006, France
c Inserm U1016, Institut Cochin, 22 rue Méchain, Paris 75014, France
d Université Paris-Saclay, CentraleSupélec, Mathématiques et Informatique pour la Complexité et les Systèmes, Gif-sur-Yvette, France, 3 Rue Joliot Curie, Gif-sur-Yvette 91190, France
e Université Paris-Saclay, CentraleSupélec, Inria, Gif-sur-Yvette, France
f Gustave Roussy-CentraleSupélec-TheraPanacea, Noesia Center of Artificial Intelligence in Radiation Therapy and Oncology, Gustave Roussy Cancer Campus, Villejuif, France
g Université Paris-Saclay, Institut Gustave Roussy, Inserm U1030 Molecular Radiotherapy and Innovative Therapeutics, 114 Rue Edouard Vaillant, Villejuif 94800, France
h Université Paris-Saclay, Institut Gustave Roussy, Inserm U981 Predictive Biomarkers and New Therapeutic Strategies in Oncology, 114 Rue Edouard Vaillant, Villejuif 94800, France
i Université Paris-Saclay, Institut Gustave Roussy, Prism Precision Medicine Center, 114 Rue Edouard Vaillant, Villejuif 94800, France
j TheraPanacea, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France
k Radiology Department, Hopital Européen Georges Pompidou - AP-HP. Centre Université de Paris, 20 Rue Université Paris-Saclay, Paris 75015, France
l Radiology Department, Hopital Beaujon - AP-HP. Nord Université de Paris, 100 Boulevard du Général Leclerc, Clichy 92110 France
m Internal Medicine Department, Hopital Beaujon - AP-HP. Nord Université de Paris, 100 Boulevard du Général Leclerc, Clichy 92110 France
n Radiology Department, Hopital Bichat - AP-HP. Nord Université de Paris, 46 Rue Henri Huchard, Paris 75018, France
o Radiology Department, Hopital Avicenne - AP-HP. Hopitaux universitaires Paris Seine-Saint-Denis, 125 Rue de Stalingrad, Bobigny 93000, France
p Université Sorbonne Paris Nord, 99 Avenue Jean Baptiste Clément, Villetaneuse 93430, France
q Radiology Department, Hopital Lariboisière - AP-HP. Nord Université de Paris, 2 Rue Ambroise Paré, Paris 75010, France
r Radiology Department, Hopital Ambroise Paré - AP-HP. Université Paris Saclay, 9 Avenue Charles de Gaulle, Boulogne-Billancourt 92100 France
s Radiology Department, Raymond-Pointcaré - AP-HP. Université Paris Saclay, 104 Boulevard Raymond Poincaré, Garches 92380, France
t Université Paris-Saclay, Espace Technologique Bat. Discovery - RD 128 - 2e ét, Saint-Aubin 91190 France